Concentrates on assessed the coinfection of HPV and C. Trachomatis and proposed that coinfection of HPV and C. Trachomatis was connected with a higher gamble of uterine cervical cancer. 

Cancer: HPV and chlamydia both increase risk Cervical cancer

Women with cervical cancer are often exposed to two pathogens beforehand: the human papilloma virus (HPV) and the bacterial pathogen Chlamydia trichomes. A German research group is now investigating the role of these infections in the development of cancer.

Cancer: HPV and chlamydia both increase risk Cervical cancer

Researchers at the Julius-Maximilians-Universität Würzburg (JMU) found that the risk of cervical cancer increased when HPV and chlamydia infections were present.

The effect proved for the first time.

It has already been assumed that the two pathogens HPV and Chlamydia trachomatis work together as a kind of team. The research group around Dr. Cinderella Chamdori has now, for the first time, been able to prove that this is not a hypothesis but a tangible effect.

 

Cervical life-like replicas

Researchers used replicas of living organs, so-called 3D organisms, for their research. Using healthy donor tissue samples, the team was able to create a physical organoid model near the cervix.

 

These models were then exposed to two pathogens. In this way, scientists have been able to document the exact link between infection and cancer development.

 

"Our study uses organoid models to show the risk of multiple infections," says Dr. Chamdori. The team specifically focused on two types of tissue in the lining of the uterus (ectosarox and endocervix) to help prevent pathogens from entering the uterus and to keep the upper female reproductive tract sterile. Are made.

Cervical cancer often develops in the mucous membranes

"Areas where the active- and endocrine systems combine to form a transition zone and are particularly susceptible to infection and neoplasms," says the research leader. According to him, most cervical cancers are born there.

Alliance between HPV and Chlamydia

HPV and C. trachomatis are "among the most well-known physically communicated microorganisms," accentuates Dr. Stephanie Coaster, one of the primary creators of this review. It has for quite some time been demonstrated that HPV can cause malignant growth. That is why vaccines have been available since 2007.

 

 

According to the research team, HPV viral DNA can be found in more than 90% of cases of cervical cancer. However, researchers emphasize that the virus may not be the only cause.

 

Exposure to Chlamydia is known to be an important factor in the development of malignant tissue. "However, the dynamics and basic mechanisms of this joint were largely unknown until now," reports Dr. Rajendra Kumar Groomurthy, another first author of the study.

 

Bacteria rarely leave marks

So far, however, the connection is difficult to prove because, unlike viruses, bacteria rarely leave identifiable elements in cancer cells. Using organoid models, this connection can now be understood for the first time.

 

HPV and Chlamydia reprogram cells.

"Our analysis shows that HPV and Chlamydia cause a unique cellular reprogramming of the host," Chumduri summarizes the key findings. According to scientists, many genes are regulated in different ways by two pathogens up or down.

 

This process is associated with, among other things, specific immune responses and effects to repair DNA damage. This "creates a unique cellular micro-environment that potentially contributes to tissue reprogramming and thus cancer development."

 

Organizations open up new avenues for research.

At the same time, the team is showing a new way of studying cervix. Organdies can also be used in a variety of contexts, for example to test drugs that affect the organ or other diseases.

 

This article contains general data just and ought not be utilized for self-conclusion or treatment. It can't replace the doctor's visit.